Marion, Crittenden County, Mattoon, Sturgis and Salem fire departments were called to the scene as well as EMS, state police, sheriff's department, PHI air ambulance and other agencies.
The fire started at about 4 p.m.
Glenda Tinsley was stuck on the upper floor of the home called 911 and reported the fire. When the first responders arrived, they heard screams coming from the home but were be unable to enter the burning structure.
The house was fully engulfed by the time firefighters arrived. Tinsley is believed to have perished in the fire. Investigators were still on the scene late Tuesday evening.
More information as it becomes available.